ALNYLAM PHARMACEUTICALS INC

NASDAQ: ALNY (Alnylam Pharmaceuticals, Inc.)

Last update: 27 Oct, 9:46AM

477.06

13.63 (2.94%)

Previous Close 463.43
Open 465.56
Volume 395,667
Avg. Volume (3M) 1,183,028
Market Cap 62,532,554,752
Price / Earnings (Forward) 46.51
Price / Sales 24.25
Price / Book 241.13
52 Weeks Range
205.87 (-56%) — 495.55 (3%)
Earnings Date 30 Oct 2025
Profit Margin -11.49%
Operating Margin (TTM) 3.04%
Diluted EPS (TTM) -2.11
Quarterly Revenue Growth (YOY) 20.20%
Total Debt/Equity (MRQ) 2,358.25%
Current Ratio (MRQ) 3.04
Operating Cash Flow (TTM) -45.11 M
Levered Free Cash Flow (TTM) 223.09 M
Return on Assets (TTM) -1.79%

Market Trend

Short Term Medium Term
Industry Biotechnology (US) Mixed Mixed
Biotechnology (Global) Mixed Mixed
Stock Alnylam Pharmaceuticals, Inc. Bullish Bullish

AIStockmoo Score

0.5
Analyst Consensus 1.5
Insider Activity NA
Price Volatility -0.5
Technical Moving Averages 1.5
Technical Oscillators -0.5
Average 0.50

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Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam has five drugs on the market: Onpattro and Amvuttra for hATTR amyloidosis, Givlaari for acute hepatic porphyria, Oxlumo for primary hyperoxaluria type 1, and Leqvio for hypercholesterolemia. It also has several clinical programs across various therapeutic areas: genetic medicines; cardio-metabolic diseases; hepatic infectious diseases, and CNS/ocular diseases. Upfront fees from research partnerships have boosted Alnylam's cash levels, and the company stands to see additional milestones and royalties from drugs commercialized under collaboration partnerships.

Sector Healthcare
Industry Biotechnology
Investment Style Mid Core
% Held by Insiders 3.81%
% Held by Institutions 97.56%

Ownership

Name Date Shares Held
Regeneron Pharmaceuticals, Inc. 30 Jun 2025 4,444,445
52 Weeks Range
205.87 (-56%) — 495.55 (3%)
Price Target Range
470.00 (-1%) — 583.00 (22%)
High 583.00 (Citigroup, 22.21%) Buy
Median 517.53 (8.48%)
Low 470.00 (BMO Capital, -1.48%) Buy
Average 519.08 (8.81%)
Total 13 Buy, 1 Hold
Avg. Price @ Call 457.85
Firm Date Target Price Call Price @ Call
Barclays 31 Oct 2025 527.00 (10.47%) Buy 456.04
Piper Sandler 31 Oct 2025 489.00 (2.50%) Buy 456.04
Jefferies 30 Oct 2025 549.00 (15.08%) Buy 449.56
Truist Securities 17 Oct 2025 535.00 (12.15%) Buy 481.67
JP Morgan 13 Oct 2025 473.00 (-0.85%) Buy 464.95
HC Wainwright & Co. 10 Oct 2025 570.00 (19.48%) Buy 460.46
02 Sep 2025 570.00 (19.48%) Buy 447.00
Morgan Stanley 06 Oct 2025 475.00 (-0.43%) Hold 452.00
Stifel 06 Oct 2025 495.00 (3.76%) Buy 452.00
RBC Capital 19 Sep 2025 500.00 (4.81%) Buy 453.56
B of A Securities 17 Sep 2025 520.00 (9.00%) Buy 451.73
Goldman Sachs 16 Sep 2025 566.00 (18.64%) Buy 461.24
Evercore ISI Group 11 Sep 2025 515.05 (7.96%) Buy 468.58
BMO Capital 08 Sep 2025 470.00 (-1.48%) Buy 455.03
Citigroup 02 Sep 2025 583.00 (22.21%) Buy 447.00
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No data within this time range.

Date Type Details
04 Nov 2025 Announcement Alnylam to Webcast Presentations at Upcoming November Investor Conferences
30 Oct 2025 Announcement Alnylam Pharmaceuticals Reports Third Quarter 2025 Financial Results and Highlights Recent Period Progress
16 Oct 2025 Announcement Alnylam to Webcast Conference Call Discussing Third Quarter 2025 Financial Results
01 Oct 2025 Announcement Alnylam Announces First Patient Dosed in ZENITH Global Phase 3 Cardiovascular Outcomes Trial of Zilebesiran
28 Sep 2025 Announcement New Data from HELIOS-B Phase 3 Study Demonstrate Lower Rates of Gastrointestinal Events in ATTR-CM Patients Treated with Vutrisiran
18 Sep 2025 Announcement Alnylam Pharmaceuticals joins Alliance for Genomic Discovery, expanding diverse clinical genomic dataset to drive precision medicine
09 Sep 2025 Announcement Alnylam Announces Pricing of Upsized Offering of $575 Million Convertible Senior Notes
08 Sep 2025 Announcement Alnylam Announces Proposed Offering of $500 Million Convertible Senior Notes
31 Aug 2025 Announcement New Data From Landmark HELIOS-B Phase 3 Study Presented at ESC Congress 2025 Demonstrate Vutrisiran’s Long-Term Cardiovascular Benefit in ATTR-CM
30 Aug 2025 Announcement Alnylam to Advance Zilebesiran into Global Phase 3 Cardiovascular Outcomes Trial
30 Aug 2025 Announcement Genentech and Alnylam Advance Zilebesiran Into Global Phase III Cardiovascular Outcomes Trial for People With Uncontrolled Hypertension
27 Aug 2025 Announcement Alnylam to Webcast Presentations at Upcoming September Investor Conferences
11 Aug 2025 Announcement Alnylam to Present Progress in Transforming the Treatment of Cardiovascular Disease with RNAi Therapeutics at European Society of Cardiology Congress 2025
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The support, resistance and trendline levels presented has been generated by an artificial intelligence (AI) model and should be interpreted with caution.

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