IONIS PHARMACEUTICALS INC

NASDAQ: IONS (Ionis Pharmaceuticals, Inc.)

Last update: 5 hours ago

42.93

-0.98 (-2.23%)

Previous Close 43.91
Open 43.80
Volume 3,013,739
Avg. Volume (3M) 3,197,387
Market Cap 7,134,292,992
Price / Sales 10.12
Price / Book 20.49
52 Weeks Range
42.08 (-1%) — 86.74 (102%)
Earnings Date 4 Nov 2026
Profit Margin -63.86%
Operating Margin (TTM) -111.59%
Diluted EPS (TTM) -2.99
Quarterly Revenue Growth (YOY) 10.10%
Total Debt/Equity (MRQ) 413.80%
Current Ratio (MRQ) 9.66
Operating Cash Flow (TTM) -501.78 M
Levered Free Cash Flow (TTM) -368.16 M
Return on Assets (TTM) -10.59%
Return on Equity (TTM) -118.62%

Market Trend

Short Term Medium Term
Industry Biotechnology (US) Mixed Bullish
Biotechnology (Global) Mixed Bullish
Stock Ionis Pharmaceuticals, Inc. Mixed Bullish

AIStockmoo Score

1.8
Analyst Consensus NA
Insider Activity NA
Price Volatility 5.0
Technical Moving Averages 1.0
Technical Oscillators -0.5
Relative Valuation NA
Financial Health NA
AI Insight NA
Weighted Average 1.83

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Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis received FDA approval in 2024 for Tryngolza for a rare high-triglyceride syndrome, marking its first independent launch.

Sector Healthcare
Industry Biotechnology
Investment Style Small Core
% Held by Insiders 0.83%
% Held by Institutions 108.17%

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