IONIS PHARMACEUTICALS INC
NASDAQ: IONS (Ionis Pharmaceuticals, Inc.)
Last update: 1 hour ago84.35
0.06 (0.07%)
| Previous Close | 84.29 |
| Open | 84.21 |
| Volume | 1,104,161 |
| Avg. Volume (3M) | 2,348,675 |
| Market Cap | 13,662,540,800 |
| Price / Earnings (Forward) | 90.91 |
| Price / Sales | 14.21 |
| Price / Book | 22.67 |
| 52 Weeks Range | |
| Earnings Date | 25 Feb 2026 |
| Profit Margin | -63.86% |
| Operating Margin (TTM) | -111.59% |
| Diluted EPS (TTM) | -2.99 |
| Quarterly Revenue Growth (YOY) | 10.10% |
| Total Debt/Equity (MRQ) | 413.80% |
| Current Ratio (MRQ) | 9.66 |
| Operating Cash Flow (TTM) | -501.78 M |
| Levered Free Cash Flow (TTM) | -368.16 M |
| Return on Assets (TTM) | -10.59% |
| Return on Equity (TTM) | -118.62% |
Market Trend
| Short Term | Medium Term | ||
| Industry | Biotechnology (US) | Bullish | Mixed |
| Biotechnology (Global) | Bullish | Mixed | |
| Stock | Ionis Pharmaceuticals, Inc. | Bearish | Bullish |
AIStockmoo Score
| Analyst Consensus | 2.0 |
| Insider Activity | -1.0 |
| Price Volatility | -0.5 |
| Technical Moving Averages | -1.0 |
| Technical Oscillators | 4.0 |
| Average | 0.70 |
|
Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis received FDA approval in 2024 for Tryngolza for a rare high-triglyceride syndrome, marking its first independent launch. |
|
| Sector | Healthcare |
| Industry | Biotechnology |
| Investment Style | Small Core |
| % Held by Insiders | 0.83% |
| % Held by Institutions | 108.17% |
Ownership
| Name | Date | Shares Held |
|---|---|---|
| Bellevue Group Ag | 30 Sep 2025 | 6,244,451 |
| Deep Track Capital, Lp | 30 Sep 2025 | 3,808,144 |
| Tweedy, Browne Co Llc | 31 Dec 2025 | 2,464,930 |
| Two Sigma Advisers, Lp | 30 Sep 2025 | 2,073,111 |
| 52 Weeks Range | ||
| Price Target Range | ||
| High | 100.00 (Wells Fargo, 18.55%) | Buy |
| 100.00 (Leerink Partners, 18.55%) | Buy | |
| Median | 97.00 (15.00%) | |
| Low | 87.00 (Piper Sandler, 3.14%) | Buy |
| Average | 95.80 (13.57%) | |
| Total | 5 Buy | |
| Avg. Price @ Call | 80.15 | |
| Firm | Date | Target Price | Call | Price @ Call |
|---|---|---|---|---|
| Piper Sandler | 06 Feb 2026 | 87.00 (3.14%) | Buy | 86.50 |
| Wells Fargo | 05 Jan 2026 | 100.00 (18.55%) | Buy | 78.53 |
| RBC Capital | 17 Dec 2025 | 95.00 (12.63%) | Buy | 77.08 |
| Leerink Partners | 15 Dec 2025 | 100.00 (18.55%) | Buy | 79.76 |
| B of A Securities | 09 Dec 2025 | 97.00 (15.00%) | Buy | 78.86 |
| Name | Avg. Buy ($) | Avg. Sell ($) | Net Quantity | Net Value ($) |
|---|---|---|---|---|
| BAROLDI JOSEPH | 83.88 | 82.67 | 4,982 | 424,298 |
| BENNETT C FRANK | 83.88 | 82.87 | -79,553 | -6,596,863 |
| BIRCHLER BRIAN | 83.88 | 82.67 | 5,812 | 494,987 |
| HOUGEN ELIZABETH L | 83.88 | 82.67 | 6,574 | 559,883 |
| MONIA BRETT P | 83.88 | 82.67 | 59,244 | 5,045,580 |
| O'NEIL PATRICK R. | 83.88 | 82.67 | 5,812 | 494,987 |
| SCHNEIDER EUGENE | 83.88 | 82.67 | 5,812 | 494,987 |
| SWAYZE ERIC | 83.88 | 82.67 | 5,812 | 494,987 |
| Aggregate Net Quantity | 14,495 | |||
| Aggregate Net Value ($) | 1,412,847 | |||
| Aggregate Avg. Buy ($) | 83.88 | |||
| Aggregate Avg. Sell ($) | 82.71 | |||
| Name | Holder | Date | Type | Quantity | Price | Value ($) |
|---|---|---|---|---|---|---|
| BENNETT C FRANK | Officer | 02 Feb 2026 | Sell (-) | 85,089 | 83.07 | 7,068,343 |
| BENNETT C FRANK | Officer | 02 Feb 2026 | Option execute | 65,089 | - | - |
| BENNETT C FRANK | Officer | 30 Jan 2026 | Sell (-) | 5,885 | 82.67 | 486,513 |
| BAROLDI JOSEPH | Officer | 30 Jan 2026 | Sell (-) | 5,296 | 82.67 | 437,820 |
| BIRCHLER BRIAN | Officer | 30 Jan 2026 | Sell (-) | 6,179 | 82.67 | 510,818 |
| HOUGEN ELIZABETH L | Officer | 30 Jan 2026 | Sell (-) | 6,988 | 82.67 | 577,698 |
| MONIA BRETT P | Officer | 30 Jan 2026 | Sell (-) | 62,970 | 82.67 | 5,205,730 |
| SCHNEIDER EUGENE | Officer | 30 Jan 2026 | Sell (-) | 6,179 | 82.67 | 510,818 |
| O'NEIL PATRICK R. | Officer | 30 Jan 2026 | Sell (-) | 6,179 | 82.67 | 510,818 |
| SWAYZE ERIC | Officer | 30 Jan 2026 | Sell (-) | 6,179 | 82.67 | 510,818 |
| BENNETT C FRANK | Officer | 29 Jan 2026 | Acquired (+) | 11,421 | 83.88 | 957,993 |
| BAROLDI JOSEPH | Officer | 29 Jan 2026 | Acquired (+) | 10,278 | 83.88 | 862,119 |
| BIRCHLER BRIAN | Officer | 29 Jan 2026 | Acquired (+) | 11,991 | 83.88 | 1,005,805 |
| HOUGEN ELIZABETH L | Officer | 29 Jan 2026 | Acquired (+) | 13,562 | 83.88 | 1,137,581 |
| MONIA BRETT P | Officer | 29 Jan 2026 | Acquired (+) | 122,214 | 83.88 | 10,251,310 |
| SCHNEIDER EUGENE | Officer | 29 Jan 2026 | Acquired (+) | 11,991 | 83.88 | 1,005,805 |
| O'NEIL PATRICK R. | Officer | 29 Jan 2026 | Acquired (+) | 11,991 | 83.88 | 1,005,805 |
| SWAYZE ERIC | Officer | 29 Jan 2026 | Acquired (+) | 11,991 | 83.88 | 1,005,805 |
| Show more | ||||||
The support, resistance and trendline levels presented has been generated by an artificial intelligence (AI) model and should be interpreted with caution.
Portfolio
| Realized Profit | - |
| Unrealized Profit | - |
| Dividend Received 2026 | - |
| Total Profit | - |
| Avg. Return | - |
| Quantity (Buy) | - |
| Avg. Price (Buy) | - |
| Quantity (Sold) | - |
| Avg. Price (Sold) | - |