SPYRE THERAPEUTICS INC.

NASDAQ: SYRE (Spyre Therapeutics, Inc.)

Last update: 24 Nov, 11:46PM

26.97

2.71 (11.17%)

Previous Close 24.26
Open 24.95
Volume 912,989
Avg. Volume (3M) 846,525
Market Cap 2,092,659,584
Price / Sales 650.22
Price / Book 8.67
52 Weeks Range
10.91 (-59%) — 29.06 (7%)
Earnings Date 4 Nov 2025
Diluted EPS (TTM) -3.06
Total Debt/Equity (MRQ) 0.06%
Current Ratio (MRQ) 8.06
Operating Cash Flow (TTM) -169.86 M
Levered Free Cash Flow (TTM) -68.57 M
Return on Assets (TTM) -25.34%
Return on Equity (TTM) -65.82%

Market Trend

Short Term Medium Term
Industry Biotechnology (US) Mixed Mixed
Biotechnology (Global) Mixed Mixed
Stock Spyre Therapeutics, Inc. Bullish Bearish

AIStockmoo Score

1.8
Analyst Consensus 5.0
Insider Activity NA
Price Volatility -4.5
Technical Moving Averages 2.5
Technical Oscillators 4.0
Average 1.75

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Spyre Therapeutics Inc is a biotechnology company that aims to create the next-generation of inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations, and precision medicine approaches for patient selection. IBD is a chronic condition characterized by inflammation within the gastrointestinal tract, including two main disorders which are UC and CD. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.

Sector Healthcare
Industry Biotechnology
Investment Style Small Value
% Held by Insiders 8.71%
% Held by Institutions 106.07%
52 Weeks Range
10.91 (-59%) — 29.06 (7%)
Price Target Range
43.00 (59%) — 70.00 (159%)
High 70.00 (BTIG, 159.55%) Buy
Median 64.00 (137.30%)
Low 43.00 (Deutsche Bank, 59.44%) Buy
Average 59.00 (118.76%)
Total 3 Buy
Avg. Price @ Call 19.91
Firm Date Target Price Call Price @ Call
Jones Trading 01 Dec 2025 64.00 (137.30%) Buy 28.66
Deutsche Bank 26 Sep 2025 43.00 (59.44%) Buy 16.24
BTIG 16 Sep 2025 70.00 (159.55%) Buy 14.82

No data within this time range.

Date Type Details
05 Dec 2025 Announcement Spyre Therapeutics Announces Grants of Inducement Awards
07 Nov 2025 Announcement Spyre Therapeutics Announces Grants of Inducement Awards
04 Nov 2025 Announcement Spyre Therapeutics Reports Third Quarter 2025 Financial Results and Provides Corporate Update
04 Nov 2025 Announcement Spyre Therapeutics Announces Positive Interim Phase 1 Results for SPY003, Its Novel, Half-Life Extended anti-IL-23 Antibody
29 Oct 2025 Announcement Spyre Therapeutics to Participate in Upcoming November Investor Conferences
24 Oct 2025 Announcement Spyre Therapeutics Announces Poster Presentations at American College of Rheumatology (ACR) Convergence 2025
15 Oct 2025 Announcement Spyre Therapeutics, Inc. Announces Closing of Public Offering and Full Exercise of the Underwriters’ Option to Purchase Additional Shares for Gross Proceeds of $316.2 Million
13 Oct 2025 Announcement Spyre Therapeutics Announces Pricing of $275.0 Million Public Offering of Common Stock
13 Oct 2025 Announcement Spyre Therapeutics Announces Proposed Public Offering of its Common Stock and Pre-Funded Warrants
05 Oct 2025 Announcement Spyre Therapeutics Announces Poster Presentations at United European Gastroenterology Week (UEGW) 2025
03 Oct 2025 Announcement Spyre Therapeutics Announces Grants of Inducement Awards
15 Sep 2025 Announcement Spyre Therapeutics Doses First Patient in Pioneering Phase 2 SKYWAY Basket Trial of SPY072, the First Anti-TL1A Antibody Studied in Rheumatic Diseases
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