SPYRE THERAPEUTICS INC.

NASDAQ: SYRE (Spyre Therapeutics, Inc.)

Last update: 24 Nov, 2025, 11:46PM

26.97

2.71 (11.17%)

Previous Close 24.26
Open 24.95
Volume 912,989
Avg. Volume (3M) 846,525
Market Cap 2,092,659,584
Price / Sales 650.22
Price / Book 8.29
52 Weeks Range
10.91 (-59%) — 29.06 (7%)
Earnings Date 4 Nov 2025
Diluted EPS (TTM) -3.06
Total Debt/Equity (MRQ) 0.06%
Current Ratio (MRQ) 8.06
Operating Cash Flow (TTM) -169.86 M
Levered Free Cash Flow (TTM) -68.57 M
Return on Assets (TTM) -25.34%
Return on Equity (TTM) -65.82%

Market Trend

Short Term Medium Term
Industry Biotechnology (US) Bullish Mixed
Biotechnology (Global) Bullish Mixed
Stock Spyre Therapeutics, Inc. Bullish Bullish

AIStockmoo Score

0.8
Analyst Consensus 5.0
Insider Activity 3.0
Price Volatility -4.5
Technical Moving Averages 0.0
Technical Oscillators 0.5
Average 0.80

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QURE 2 B - - 6.44

Spyre Therapeutics Inc is a biotechnology company that aims to create the next-generation of inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations, and precision medicine approaches for patient selection. IBD is a chronic condition characterized by inflammation within the gastrointestinal tract, including two main disorders which are UC and CD. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.

Sector Healthcare
Industry Biotechnology
Investment Style Small Value
% Held by Insiders 8.71%
% Held by Institutions 106.07%
52 Weeks Range
10.91 (-59%) — 29.06 (7%)
Price Target Range
53.00 (96%) — 70.00 (159%)
High 70.00 (BTIG, 159.55%) Buy
Median 64.00 (137.30%)
Low 53.00 (Mizuho, 96.52%) Buy
Average 62.75 (132.67%)
Total 4 Buy
Avg. Price @ Call 32.11
Firm Date Target Price Call Price @ Call
BTIG 16 Jan 2026 70.00 (159.55%) Buy 33.24
Mizuho 18 Dec 2025 53.00 (96.51%) Buy 33.47
Citigroup 17 Dec 2025 64.00 (137.30%) Buy 33.06
Jones Trading 01 Dec 2025 64.00 (137.30%) Buy 28.66

No data within this time range.

The support, resistance and trendline levels presented has been generated by an artificial intelligence (AI) model and should be interpreted with caution.

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