UPSTREAM BIO, INC.

NASDAQ: UPB (Upstream Bio, Inc.)

Last update: 3 hours ago

9.88

-0.46 (-4.45%)

Previous Close 10.34
Open 10.40
Volume 540,506
Avg. Volume (3M) 1,320,821
Market Cap 537,669,440
Price / Sales 195.11
Price / Book 1.66
52 Weeks Range
7.25 (-26%) — 33.68 (240%)
Earnings Date 5 May 2026
Operating Margin (TTM) -5,656.01%
Diluted EPS (TTM) -1.67
Quarterly Revenue Growth (YOY) -11.60%
Total Debt/Equity (MRQ) 0.38%
Current Ratio (MRQ) 47.43
Operating Cash Flow (TTM) -82.78 M
Levered Free Cash Flow (TTM) -70.18 M
Return on Assets (TTM) -16.91%
Return on Equity (TTM) -28.62%

Market Trend

Short Term Medium Term
Industry Biotechnology (US) Bullish Mixed
Biotechnology (Global) Bullish Mixed
Stock Upstream Bio, Inc. Mixed Bearish

AIStockmoo Score

0.5
Analyst Consensus 2.0
Insider Activity NA
Price Volatility -2.0
Technical Moving Averages 0.0
Technical Oscillators 2.0
Average 0.50

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Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).

Sector Healthcare
Industry Biotechnology
Investment Style Small Value
% Held by Insiders 14.84%
% Held by Institutions 89.32%

Ownership

Name Date Shares Held
Decheng Capital Llc 31 Dec 2025 3,143,078
Altshuler Shaham Ltd 31 Dec 2025 1,341,540
Bain Capital Life Sciences Investors, Llc 31 Dec 2025 1,329,544
Omega Fund Management, Llc 31 Dec 2025 1,326,293

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The support, resistance and trendline levels presented has been generated by an artificial intelligence (AI) model and should be interpreted with caution.

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