VERTEX PHARMACEUTICALS INC

NASDAQ: VRTX (Vertex Pharmaceuticals Incorpor)

Last update: 22 hours ago

432.17

2.35 (0.55%)

Previous Close 429.82
Open 432.43
Volume 1,110,066
Avg. Volume (3M) 1,495,364
Market Cap 110,804,353,024
Price / Earnings (TTM) 30.39
Price / Earnings (Forward) 22.37
Price / Sales 9.40
Price / Book 6.25
52 Weeks Range
362.50 (-16%) — 519.68 (20%)
Earnings Date 3 Nov 2025
Profit Margin -8.91%
Operating Margin (TTM) 37.22%
Diluted EPS (TTM) -3.80
Quarterly Revenue Growth (YOY) 3.00%
Quarterly Earnings Growth (YOY) -41.20%
Total Debt/Equity (MRQ) 10.00%
Current Ratio (MRQ) 2.65
Operating Cash Flow (TTM) -980.30 M
Levered Free Cash Flow (TTM) 2.63 B
Return on Assets (TTM) 11.77%
Return on Equity (TTM) -5.64%

Market Trend

Short Term Medium Term
Industry Biotechnology (US) Mixed Mixed
Biotechnology (Global) Mixed Mixed
Stock Vertex Pharmaceuticals Incorpor Bearish Bearish

AIStockmoo Score

-0.1
Analyst Consensus -0.5
Insider Activity -5.0
Price Volatility 2.0
Technical Moving Averages 2.5
Technical Oscillators 0.5
Average -0.10

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CRSP 5 B - - 2.65
TLX 3 B - 487.50 7.77

Vertex Pharmaceuticals is a global biotechnology company that discovers and develops small-molecule drugs for the treatment of serious diseases. Its key drugs are Kalydeco, Orkambi, Symdeko, and Trikafta/Kaftrio for cystic fibrosis, where Vertex therapies remain the standard of care globally. Vertex has diversified its portfolio through Casgevy, a gene-editing therapy for beta thalassemia and sickle-cell disease. Additionally, Vertex is evaluating small-molecule inhibitors targeting acute and chronic pain using nonopioid treatments, and small-molecule inhibitors of APOL1-mediated kidney diseases. Vertex is also investigating cell therapies to deliver a potential functional cure for type 1 diabetes.

Sector Healthcare
Industry Biotechnology
Investment Style Large Value
% Held by Insiders 0.15%
% Held by Institutions 97.64%
52 Weeks Range
362.50 (-16%) — 519.68 (20%)
Price Target Range
414.00 (-4%) — 575.00 (33%)
High 575.00 (Citigroup, 33.05%) Buy
Median 456.00 (5.51%)
Low 414.00 (Barclays, -4.20%) Hold
Average 477.11 (10.40%)
Total 5 Buy, 4 Hold
Avg. Price @ Call 410.17
Firm Date Target Price Call Price @ Call
UBS 07 Nov 2025 546.00 (26.34%) Buy 409.47
Barclays 04 Nov 2025 414.00 (-4.20%) Hold 421.67
RBC Capital 04 Nov 2025 415.00 (-3.97%) Hold 421.67
Stifel 04 Nov 2025 445.00 (2.97%) Hold 421.67
Morgan Stanley 10 Oct 2025 438.00 (1.35%) Hold 407.79
JP Morgan 08 Oct 2025 530.00 (22.64%) Buy 421.15
Citigroup 02 Oct 2025 575.00 (33.05%) Buy 408.85
Leerink Partners 25 Sep 2025 456.00 (5.51%) Buy 381.87
Evercore ISI Group 11 Sep 2025 475.00 (9.91%) Buy 397.37
Name Avg. Buy ($) Avg. Sell ($) Net Quantity Net Value ($)
ATKINSON EDWARD MORROW III - 434.02 -2,500 -1,085,050
CARNEY LLOYD - 421.03 -800 -336,824
LEIDEN JEFFREY M - 437.15 -53,604 -23,432,989
Aggregate Net Quantity -56,904
Aggregate Net Value ($) -24,854,863
Aggregate Avg. Buy ($) -
Aggregate Avg. Sell ($) 430.73
Name Holder Date Type Quantity Price Value ($)
CARNEY LLOYD Director 19 Nov 2025 Disposed (-) 800 421.03 336,824
ATKINSON EDWARD MORROW III Officer 17 Nov 2025 Automatic sell (-) 2,500 434.02 1,085,050
LEIDEN JEFFREY M Officer 14 Nov 2025 Automatic sell (-) 53,604 437.15 23,432,989
LEIDEN JEFFREY M Officer 14 Nov 2025 Option execute 53,604 - -
Date Type Details
19 Nov 2025 Announcement Vertex to Participate in the Citi’s 2025 Global Healthcare Conference on December 3
08 Nov 2025 Announcement Vertex Presents Updated Phase 1/2 Data From RUBY-3 Study That Continue to Demonstrate Best-in-Class Potential for Povetacicept in Adults with IgA Nephropathy and Primary Membranous Nephropathy at American Society of Nephrology Kidney Week
03 Nov 2025 Announcement Vertex Reports Third Quarter 2025 Financial Results
27 Oct 2025 Announcement Vertex to Participate in the UBS Global Healthcare Conference on November 11
23 Oct 2025 Announcement Vertex Presents New Data Across Portfolio of Cystic Fibrosis Medicines Including ALYFTREK® at the North American Cystic Fibrosis Conference
17 Oct 2025 Announcement Vertex Announces Progress in Povetacicept Development Program and Presentation of New Data at American Society of Nephrology Kidney Week
06 Oct 2025 Announcement Vertex to Announce Third Quarter 2025 Financial Results on November 3rd
25 Sep 2025 Announcement Vertex Announces Key Advancements Across Kidney Portfolio
23 Sep 2025 Announcement Vertex Partners with Basketball World Champion Jayson Tatum to Raise Awareness of JOURNAVX®, a Non-Opioid Medicine Approved for the Treatment of Moderate-to-Severe-Acute Pain
18 Sep 2025 Announcement Vertex Announces CASGEVY® Reimbursement Agreement for the Treatment of Transfusion-Dependent Beta Thalassemia and Sickle Cell Disease in Italy
11 Sep 2025 Announcement Vertex Scientists Awarded the 2025 Lasker~DeBakey Clinical Medical Research Award for Pioneering Discoveries in Cystic Fibrosis
02 Sep 2025 Announcement Enlaza Therapeutics Announces Strategic Collaboration with Vertex Pharmaceuticals to Develop War-Lock Drug Conjugates and T-Cell Engagers for Improved Conditioning and Certain Autoimmune Diseases
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